Browsing by Author "Jabbar, Abdul"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Green synthesized polyscias fulva silver nanoparticles ameliorate uterine fibroids in female wistar albino rats.
    (PLOS One, 2025) Kiyimba, Kenedy; Ahmed, Ayaz; Choudhary, Muhammad Iqbal; Rehman, Khadija; Hasan, Syed Mehmood; Jabbar, Abdul; Obakiro, Samuel Baker; Shah, Muhammad Raza; Munyendo, Were Lincoln; Guantai, Eric M.; Gavamukulya, Yahaya
    Uterine fibroids affect a substantial proportion of women in their reproductive age. Despite their effectiveness, surgical options such as hysterectomy are invasive, costly, and associated with recurrences. Pharmacological treatments are noncurative, only alleviate symptoms, and associated with adverse effects. Polyscias fulva (Araliaceae) is traditionally used to manage uterine fibroids in East Africa. In this study we synthesized Polyscias fulva silver nanoparticles (PFAgNPs), evaluated their toxicity and activity against monosodium glutamate (MSG)-induced uterine fibroids in Wistar albino rats. The UV-visible spectroscopy showed maximal absorbance at 425nm with adequate stability at varying temperatures, pH and storage conditions. Dynamic light scattering (DLS) analysis revealed an average hydrodynamic size of 107.4 d.nm, polydispersity index of 0.264, and zeta potential of -18.3 mV. X-ray diffraction (XRD) confirmed the crystalline nature of PFAgNPs with an average size of 25nm while scanning electron microscopy (SEM) showed a spherical shape with an average size of 35nm. The PFAgNPs caused lethargy, hyperventilation, and hyperactivity at a dose of 300mg/kg BW, whereas 2000mg/kg caused severe toxicity, resulting in death in acute toxicity testing. The no observed adverse effect level was 50mg/kgBW, the lowest observed adverse effect level was 100mg/kgBW, and median lethal dose (LD50) was 1000mg/kg. The PFAgNPs significantly decreased (P<0.05) serum proteins, cholesterol, estrogen and progesterone alongside preservation of the histoarchitecture of the uterus. Further research is needed to investigate the clinical safety of PFAgNPs in managing uterine fibroids.
  • No Thumbnail Available
    Item
    Nanocellulose coated woven jute/green epoxy composites : characterization of mechanical and dynamic mechanical behavior.
    (Elsevier, 2016) Jabbar, Abdul; Militký, Jiř í; Jakub, Wiener; Bandu, Madhukar Kale; Usman, Ali; Rwawiire, Samson
    This paper presents the preparation and characterization of nanocellulose coated woven jute/green epoxy composites. Waste jute fibers were used as precursor to purify and extract nanocellulose by chemical treatments. The prepared suspensions with 3, 5 and 10 wt% of nanocellulose were coated over jute fabric followed by preparation of composites by compression molding technique. The surface morphologies of treated jute fibers, jute cellulose nanofibrils (CNF), nanocellulose coated jute fabrics and fractured surfaces of composites were characterized by scanning electron microscopy (SEM). The crystallinity of jute fibers after different chemical treatments was measured by X-ray diffraction (XRD). The effect of nanocellulose coating over jute reinforcement on the tensile, flexural, fracture toughness and dynamic mechanical properties of prepared composites has been investigated. Fracture toughness was measured using single end notched bend (SENB) specimens and dynamic mechanical test was performed in three point bending mode. The results revealed the improvement in tensile Samson modulus, flexural properties and fracture toughness except the decrease in tensile strength of nanocellulose coated woven jute/green epoxy composites as compared to uncoated jute composite. Dynamic mechanical analysis (DMA) results also showed the increase in storage modulus and reduction in tangent delta peak height of nanocellulose coated jute composites. Keywords: Jute fibers, nanocellulose coating, mechanical properties, fracture toughness, dynamic mechanical analysis.