Browsing by Author "Okibure, Ambrose"

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    Coping mechanisms for students with mental disorders : an exploratory qualitative study at Busitema University’s Mbale and Busia campuses.
    (PLOS One, 2025) Kagoya, Enid Kawala; Mpagi, Joseph; Waako, Paul; Muhwezi, Martha R. L.; Namaganda, Agnes; Nsubuga, Allan G.; Atala, Christine Etoko; Okello, Francis; Okibure, Ambrose; Kibuuka, Ronald; Wandera, Ernest; Ndamanywa, Kalisiti; Kirabira, Joseph
    In recent years, Ugandan universities have faced a rising incidence of mental health issues among students, with prevalence rates of mental disorders reaching up to 60% among undergraduates. These challenges significantly impact both academic performance and social interactions. This study aimed to investigate the coping mechanisms among students with mental disorders at Busitema University. We conducted 42 key informant interviews with students diagnosed with mental disorders, as determined by the Mini International Neuropsychiatric Interview. Interviews were guided by a structured protocol developed by the research team, and all participants provided informed consent. The interviews were audiotaped, transcribed verbatim, and analyzed using thematic analysis. This approach was chosen for its efficiency and directness. Nvivo software facilitated the coding and organization of themes. The study identified several coping strategies used by students at the two Busitema University campuses. Five main themes emerged: Alcohol and Substance Use, Use of Sedatives, Social and Personal Initiatives, Seeking Counseling Services, Withdrawal and Confrontation, and Faith Healing. Various subthemes were also noted, including substance use, withdrawal, confrontations, witchcraft, participation in co-curricular activities, abortions, and seeking psychosocial support. These findings are detailed in Table 2. Addressing the mental health challenges faced by university students requires a thorough understanding of their coping strategies. While some strategies are self-developed, others involve university-led interventions. It is crucial to reinforce effective coping mechanisms and address detrimental ones to improve students’ mental health outcomes. Mental disorders, coping strategies, university students, Uganda
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    Prevalence and factors associated with poor hand hygiene practices among adult carers of children under five in Mbale district Uganda.
    (Scientific Reports, 2025) Nawanga, Jascenti; Alunyo, Patrick Jimmy; Wenani, Daniel; Okibure, Ambrose; Olupot-Olupot, Peter; Mukunya, David; Nekaka, Rebecca; Okolimong, Charles; Okware, Samuel; Matovu, K. B. Joseph
    Background: Proper hand hygiene reduces the risk of hygiene-related diseases among children under five years of age; however, poor hand hygiene practices remain common in many communities. This study determined the prevalence and factors associated with poor hand hygiene practices among adult caregivers of children under five years in Mbale District, Eastern Uganda, to inform context-specific interventions. Methods: We conducted a cross-sectional study in March 2023 among 320 adult caregivers of children under five years. Participants were selected using multistage sampling from three sub counties with the largest under-five populations. Structured questionnaires collected information on socio-demographics, household characteristics, knowledge of hand hygiene, and COVID-19 prevention information. Poor hand hygiene was defined as reporting handwashing at five or fewer of ten critical hand hygiene moments. Multivariable logistic regression was used to identify factors independently associated with poor hand hygiene. Results: Of the 320 caregivers enrolled, 275 (85.9%) were female. The majority were aged 25–34 years (38.4%, n=123), and over half (55.6%, n=178) had primary education. Overall, 28% (n=88) of caregivers engaged in poor hand hygiene practices. In the multivariable analysis, receiving hand hygiene information from Village Health Teams (VHTs) was significantly associated with higher odds of poor hand hygiene (AOR 4.2; 95% CI 1.7-10.4). Caregivers who indicated that hand hygiene protects against COVID-19 had lower odds of poor hand hygiene (AOR 0.16; 95% CI 0.03-0.73). Additionally, inconsistent availability of soap, detergent, or sanitizer at handwashing stations was strongly associated with poor hand hygiene (AOR 8.22; 95% CI 2.03-57.16). No significant associations were observed for education level, child’s age, or type of handwashing facility. Conclusion: Nearly three in ten adult caregivers exhibited poor hand hygiene practices. Poor hand hygiene was associated with receiving information from VHTs and inconsistent access to cleansing materials, whereas knowledge of hand hygiene’s protective benefits against COVID-19 was associated with better practices. Strengthening VHT training and ensuring reliable access to handwashing supplies may help improve hygiene behaviours in Mbale District. Keywords: Hand hygiene practices, adult caregivers, children under five, Mbale District, Uganda.
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    The association between malaria parasite geometrical mean and clinical spectrum of severe disease in a high-transmission setting in eastern Uganda : a cross-sectional study.
    (Wiley, 2025) Egiru, Isaiah Eregu Emma; Namayanja, Cate; Paasi, George; Okiror, William; Ongodia, Paul; Okalebo, Benard Charles; Muhindo, Rita; Abongo, Grace; Oguttu, Faith; Okibure, Ambrose; Okello, Francis; Tegu, Crispus; Mukunya, David; Chebet, Martin; Olupot-Olupot, Peter
    Background: Malaria burden remains significant, especially in high-transmission settings. While some data show an association between severe malaria and high-malaria parasite geometrical mean (GM), few data describe this phenomenon in malaria hightransmission settings. We described the malaria parasite GM and clinical spectrum of severe malaria in Eastern Uganda to advance understanding of its implications on disease severity and patient outcomes. Methods: We conducted a cross-sectional study in Mbale Regional Referral Hospital (MRRH), Eastern Uganda. Children admitted with severe malaria confirmed by microscopy with ages between 2 months and 12 years were enrolled in the study from September 21, 2021, to September 21, 2022. Data were collected on patient sociodemographics, clinical symptoms and signs, laboratory parameters, treatment details, and outcomes. From the blood samples collected at the bedside, blood films/smears were made. The malaria parasite count was obtained from the patients’ smears by counting the malaria parasites against 200 white blood cells (WBCs). The GMs of malaria were obtained after the logarithmic transformation of the parasite counts. Data were analyzed using Stata 15, and significant associations were reported at p values of 0.05 at 95% confidence intervals. Results: A total of 376 children with a mean age of 4.65 years were recruited, of whom 57.71% (217/376) were male. Children under 5 years constituted 61.7% (232/376). The common clinical manifestations were prostration 76.9% (289/376), jaundice 55.6% (209/376), severe anemia 48.4% (182/377), and hemoglobinuria 46.5% (175/376). The overall malaria parasite GM was 12,238.42 parasites/microliter (95% CI: 9166.72–16,339.43). The highest GM of 197,000 parasites/microliter (95% CI:40,817.64–946,368) and the lowest of 8938.185 parasites/microliter (95% CI: 5932.8–13,466.01) were observed in shock and severe anemia, respectively. Inpatient mortality was 3.4%. Conclusion: In malaria high-transmission settings of Eastern Uganda, patients with severe malaria had low parasite GMs similar to those in uncomplicated malaria. Thus, malaria parasite GM should not be relied upon to determine disease severity in these settings.