FORMULATION AND EVALUATION OF A TOPICAL ANTIFUNGAL CREAM FROM TRICHODERMA EXTRACTS
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Date
2026-09-04
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KWURES HOSEA
Abstract
Fungal skin infections are a major public health problem in Uganda, affecting many
people and increasingly showing resistance to conventional antifungal drugs. Local
communities in Nagongera traditionally use Trichoderma, a naturally occurring soil
fungus, to treat skin fungal infections because of its antifungal properties.
Trichoderma produces enzymes and secondary metabolites that inhibit and destroy
pathogenic fungi.
This study aimed to investigate the antifungal activities of Trichoderma compounds
and formulate an antifungal cream for treating skin fungal infections. Laboratory
experiments were conducted to evaluate the effectiveness of the extract and assess the
cream’s properties including pH, spreadability, viscosity, stability, washability,
texture, skin irritation, and retention time on the skin.
The formulated cream showed good physicochemical properties, stability, and
minimal skin irritation. The Trichoderma extract demonstrated effective antifungal
activity against common skin fungal pathogens.
The study concluded that Trichoderma compounds have significant potential as a
natural and effective treatment for fungal skin infections and can be successfully
formulated into a topical antifungal cream
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KWURES HOSEA