Browsing by Author "Namuganza, Hadija"

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    Synthesis,Characterization And Antibacterial Evaluation Of Dibenzalacetone As A Monocarbonyl Curcumin Analogue Against Escherichia Coli
    (Busitema University, 2026) Namuganza, Hadija
    Curcumin is a naturally occurring polyphenolic compound isolated from turmeric and is known for its antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. However, the practical application of curcumin has been limited due to its poor bioavailability and chemical instability. This research focused on the synthesis of monocarbonyl curcumin analogues and evaluation of their antimicrobial activity against Escherichia coli. The synthesized analogue was purified by recrystallization and characterized using ultraviolet-visible spectroscopy and the absorbance was found to be 0.485 at wavelength of 330nm, melting point determination and its melting point was found to be 1190 C and Fourier Transform Infrared Spectroscopy (FTIR) for functional group analysis. Antimicrobial activity was determined using agar well diffusion and minimum inhibitory concentration methods. The synthesized monocarbonyl curcumin analogue exhibited a yellow-orange crystalline appearance with a relatively sharp melting point indicating purity. UV-visible spectroscopy showed characteristic absorption peaks associated with conjugated systems while FTIR analysis confirmed the presence of aromatic rings, hydroxyl groups, carbonyl groups, and alkene functionalities. Antimicrobial evaluation demonstrated inhibitory effects against Escherichia coli.The synthesized anologue exhibited zones of 2.25, 7.25 and 10.50mm at concentrations of 0.25, 0.5 and 1.0mg/L respectively. The percentage yield of the synthesized analogue was found to be 85%. The results indicated that structural modification of curcumin improves stability and enhances antimicrobial activity. The study concludes that monocarbonyl curcumin analogues are promising antimicrobial a 9, kgents and may contribute to development of novel therapeutic compounds against resistant bacterial strains.