Synthesis,Characterization And Antibacterial Evaluation Of Dibenzalacetone As A Monocarbonyl Curcumin Analogue Against Escherichia Coli
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Date
2026
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Busitema University
Abstract
Curcumin is a naturally occurring polyphenolic compound isolated from turmeric and is known
for its antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. However, the
practical application of curcumin has been limited due to its poor bioavailability and chemical
instability. This research focused on the synthesis of monocarbonyl curcumin analogues and
evaluation of their antimicrobial activity against Escherichia coli. The synthesized analogue
was purified by recrystallization and characterized using ultraviolet-visible spectroscopy and
the absorbance was found to be 0.485 at wavelength of 330nm, melting point determination
and its melting point was found to be 1190 C and Fourier Transform Infrared Spectroscopy
(FTIR) for functional group analysis. Antimicrobial activity was determined using agar well
diffusion and minimum inhibitory concentration methods.
The synthesized monocarbonyl curcumin analogue exhibited a yellow-orange crystalline
appearance with a relatively sharp melting point indicating purity. UV-visible spectroscopy
showed characteristic absorption peaks associated with conjugated systems while FTIR
analysis confirmed the presence of aromatic rings, hydroxyl groups, carbonyl groups, and
alkene functionalities. Antimicrobial evaluation demonstrated inhibitory effects against
Escherichia coli.The synthesized anologue exhibited zones of 2.25, 7.25 and 10.50mm at
concentrations of 0.25, 0.5 and 1.0mg/L respectively. The percentage yield of the synthesized
analogue was found to be 85%. The results indicated that structural modification of curcumin
improves stability and enhances antimicrobial activity.
The study concludes that monocarbonyl curcumin analogues are promising antimicrobial a
9, kgents and may contribute to development of novel therapeutic compounds against resistant
bacterial strains.