Predictors of loss to follow-up of tuberculosis cases under the DOTS programme in Namibia

Simple item page
dc.contributor.authorKibuule, Dan
dc.contributor.authorAiases, Philomein
dc.contributor.authorRuswa, Nunurai
dc.contributor.authorRennie, Timothy William
dc.contributor.authorVerbeeck, Roger K.
dc.contributor.authorGodman, Brian
dc.contributor.authorMubita, Mwangana
dc.date.accessioned2023-08-22T14:16:27Z
dc.date.available2023-08-22T14:16:27Z
dc.date.issued2020
dc.descriptionResearch article
dc.description.abstractBackground: In Namibia, one out of every 25 cases of tuberculosis (TB) is “lost to follow-up” (LTFU). This has impacted negatively on national efforts to end the disease by 2035. The aim of this study was to determine the trends and predictors of LTFU under the directly observed treatment short-course (DOTS) programme in Namibia. Methods: The study involved a retrospective longitudinal analysis of a nationwide cohort of TB cases registered under the DOTS programme in Namibia from 2006 to 2015. The trends and predictors of LTFU among cases in the National Electronic TB Register of the National TB and Leprosy Program were respectively determined by interrupted time series and multivariate logistic regression analyses using R-Studio software. Results: Out of 104 203 TB cases, 3775 (3.6%) were LTFU. A quarter (26%) of cases with poor outcomes were due to LTFU. The annual decline in cases of LTFU was significant between the first (2005–2010) and second (2010–2015) medium-term plan period for TB programme implementation ( p=0.002). The independent predictors of LTFU were male sex ( p=0.004), 15–24 years age group ( p=0.03), provider of treatment ( p<0.001), intensive phase ( p=0.047) and living in border/transit regions ( p<0.001). HIV co-infection and TB regimen were not significant predictors of LTFU. Conclusions: There were declining trends in LTFU in Namibia. DOTS programmes should integrate socioeconomic interventions for young and middle-aged adult male TB cases to reduce LTFU.
dc.description.sponsorshipUniversity of Namibia, Karolinska Institutet, University of Liverpool Management School, Busitema University
dc.identifier.citationKibuule D, Aiases P, Ruswa N, et al. Predictors of loss to follow-up of tuberculosis cases under the DOTS programme in Namibia. ERJ Open Res 2020; 6: 00030-2019 [https://doi.org/10.1183/23120541.00030-2019].
dc.identifier.urihttps://doi.org/10.60682/dhxq-hx65
dc.language.isoen
dc.publisherERJ
dc.subjectResearch Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Infectious diseases
dc.titlePredictors of loss to follow-up of tuberculosis cases under the DOTS programme in Namibia
dc.typeArticle
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Department of Clinical Phamacology