Department of Clinical Phamacology

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    Government to roll out new vaccines
    (New Vision, 2018-04-25) Baike, Prisca
    April 24-30 is World Immunisation week. Apart from saving lives, immunisation greatly reduces illness and death from vaccine-preventable diseases. Prisca Baike looks at the new vaccines to be introduced soon.
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    How to fight malaria drug resistance
    (New Vision, 2018-04-25) Amongin, Faith
    Uganda is still stuck at the control phase despite the various interventions by government and other stake holders to reduce the prevalence like the ongoing distribution of Insecticide mosquito Treated Nets (ITN) and Indoor Residual Spraying (IRS) in mainly areas where prevalence is highest. However, one of the major complications in the fight against malaria is the issue of drug resistance; that is the reduction in the effectiveness of a medication that is used repeatedly.
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    Uganda's pharmaceutical sector growing steadily.
    (Daily Monitor, 2017-10-02) Nasasira, Roland D
    Pharmacists in Uganda have appealed to the government to invest in research if the country's pharmaceutical sector is to register remarkable growth. Mr. Samuel Opio, the secretary of (PSU), says in the past 10 years, PSU has experienced an increase in numbers of pharmacies from 450 to more than 1,000 pharmacies national wide.
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    How to start uo a pharmacy.
    (Daily Monitor, 2017-10-02) Nasasira, Roland
    About seven years ago, Mr. Benard Ainebyoona, a telecommunication engineer established a drug shop in Sonde, Mukono district. After realising that there was no pharmacy in the area, he upgraded his drug shop into a pharmacy and equipped it with a blood testing laboratory to increase on health services offered to his customers.
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    Vaccine against malaria on test trial
    (New Vision, 2018-04-25) Basudde, Elvis
    The vaccines against malaria have been the object of constant endeavor by the scientific community and pharmaceutical industries for over three decades, with little success so far. Even doctors from the National Malaria Control Programme, at the ministry of Health, have expressed pessimism, saying currently the scientific team in Uganda is not having any success story in terms of developing an in country malaria vaccine.
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    How alleged fake hepatitis vaccines were stolen
    (New Vision, 2018-04-29) Etukuri, Charles
    The Hepatitis B vaccines that were confiscated by the National Drug Authority (NDA) in March this year and declared fake, were actually not, They actually belonged to National Medical Stores (NMS) but were diverted along the supply chain and sold to private medical facilities.
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    Mobile herbalists banned
    (New Vision, 2018-05-25) Kasujja, Carol
    The National Drug Authority (NDA) yesterday, during a media breakfast announced a new crackdown on unlicensed herbalists, including hawkers and vendors of drug concoctions.
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    Wandegeya Pharmacy closed
    (Sunday Vision, 2018-04-22) Kasujja, Carol; Ssejjoba, Eddie
    The National Drug Authority has halted operations of Friecca Pharmacy in Wandegeya, a city suburb, saying it has been operating without a licence.
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    The pharmaceutical society of Uganda (PSU)
    (Daily Monitor, 2017-10-02) Kyama, Eric
    Pharmacists in Uganda have called for more support towards pharmaceutical service delivery as key stakeholders in the country's health sector. Under their umbrella body: pharmaceutical society of Uganda (PSU) the pharmacists said that many health facilities I both the private and public sector do not sufficient employ pharmacists,
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    Pharmacy students ask govt to increase health budget
    (New Vision, 2018-04-25) Ssengendo, Abdulkarim
    Pharmacy students in Uganda have urged the Government to increase the health budget and number of pharmacists being trained in the country every year.
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    Children diagnosed with diabetes
    (New Vision, 2018-04-16) Magezi, N Lilian
    Recently, a donation of half a million syringes for children with diabetes type type 1, was made through Sonia Nabela Foundation - an organisation that raises awareness about the disease in Uganda.
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    Pharmacies stopped from running retail, wholesale at a go.
    (New Vision, 2018-01-12) Kitubi, Martin
    The National Drug Authority (NDA) has stopped issuing licences to pharacies offering both wholesale and retail services due to compromising patients' privacy. Donna Kusemererwa, the executive director of NDA, revealed to New Vision that the new rule will affect new pharmacies, but those in existence will be given time to separate retail from wholesale business.
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    NDA is wrong on drug shops ban.
    (New Vision, 2018-01-18) Birungi, John Peter
    Recently the National Drug Authority issued a directive that drug shops are to be phased out in municipalities and the city. The reason given was that drug shops must be transformed into pharmacist. The reason given appears to be weak.
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    Drug shops to be phased out.
    (New Vision, 2018-01-11) Amamukirori, Betty
    Drug shops located in the city , municipalities and town councils have been given one year to either transform into pharmacies or shut down, Donna Kusemerewa, the executive director of National Drug Authority(NDA) has said. She said pharmacies are stocked with all types of drugs and can sufficiently serve the population.
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    Pharmacists petition govt over delayed registration
    (Daily Monitor., 2018-03-01) Namagembe, Lilian
    Pharmacist graduates have petitioned the ministry of health over the delayed issuance of their practising licences after finishing internship last year. In a February 27 petition signed by 56 of affected 100 phyarmacists, the graduates demand that they be registered and issused with certificates of registration within seven days
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    Pharmacists petition government over delayed registration
    (Daily Monitor, 2018-03-01) Namagembe, Lilian
    Pharmacist graduates have petitioned the Ministry of Health over delayed issuance their practicing licences after finishing internship last year.
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    Why government will give free hepatitis B vaccines
    (Daily Monitor, 2018-05-01) Ainebyoona, Emmanuel
    Health officials say they do not want to waste the drugs, which will expire in the next six months.
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    Drugs authority closes more 14 pharmacies over licences
    (Daily Monitor, 2018-05-01) Ainebyoona, Emmanuel
    The National Drug Authority (NDA) has closed 14 more pharmacies countrywide for operating without 2018 licences.
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    Government to buy new drug for sickle cell anaemia
    (Daily Monitor, 2018-03-01) Ainebyoona, Emmanuel
    The Minister of Health Dr. Ruth Aceng, has directed the National Drug Authority to register hydroxyurea as a treatment for sickle cell anaemia in a move to increase the drug's availability and accessibility
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    Comprehensive analysis of molecular markers linked to antimalarial drug resistance in Plasmodium falciparum in Northern, Northeastern and Eastern Uganda
    (Springer Nature, 2025) Olupot‑Olupot, Peter; Paasi, George; Katairo, Thomas; Alunyo, Patrick Jimmy; Nakiyemba, Alice; Ocen, Gilibrays Gilbert; Pande, Stephen; Alaroker, Florance; Okiror, William; Ocen, Emmaluel; Oula, Alex; Okalebo, Benard Charles; Ongodia, Paul; Amorut, Denis; Tukwasibwe, Stephen; Ndidde, Nabadda Susan; Sewanyana, Isaac; Nsobya, L. Samuel
    Background in Uganda, antimalarial resistance in Plasmodium falciparum poses serious public health and treatment challenges. Globally, recent data have highlighted the roles of following genes in malaria resistance: Plasmodium falciparum dihydrofolate reductase (Pfdhfr), Plasmodium falciparum dihydropteroate synthetase (Pfdhps), Plasmodium falciparum chloroquine resistance transporter (Pfcrt), Plasmodium falciparum multidrug resistance gene 1 (Pfmdr1), and Plasmodium falciparum K13 propeller domain (Pfk13). This study investigated the prevalence and characteristics of P. falciparum molecular markers linked to antimalarial resistance in Northern, Northeastern, and Eastern Uganda. Methods This cross-sectional study collected 200 dried blood samples from children (2 months to 12 years) in Northern, Eastern, and Northeastern Uganda. Samples were from malaria-positive cases confirmed by rapid diagnostic tests and microscopy. Genomic DNA was extracted from these samples and analysed using Molecular Inversion Probes to detect Plasmodium falciparum genetic mutations. The sequencing was performed on the Illumina MiSeq platform, and raw data was organized and analysed with MIPTools software. Results: The study sequenced over 50% of the samples at each site as follows: Apac 87.7% (43/49), Moroto 68.0% (34/50), Soroti 65.0% (13/20) and Mbale 53.1% (43/81). The Pfk13 A675V and C469Y mutations varied from 0 to 23.3% and 8.3–14.3%, in four sites, with consistently low prevalence in Apac. The Pfdhfr N51I and S108N mutations were fixed in all districts, while C59R was fixed in Moroto and nearing fixation (92–97%) in other regions. The emerging I164L mutation ranged from 1 to 10% in all sites. The Pfdhps A437G and K540E mutations were fixed in Soroti, with 3–5% wild-type prevalence in other sites. The A581G mutation showed 2.3% mixed genotypes in Mbale only. The Pfcrt K76T was predominantly wild type, except for 5% mutants in Mbale and Moroto. The pfmdr1 N86Y were wild type across all districts, except for 15% mixed genotypes in Soroti. Conclusion: This study reveal rising partial artemisinin resistance and widespread antifolate resistance surpassing WHO thresholds in Northern, Northeastern, and Eastern Uganda. Emerging super-resistant parasites pose a serious threat to malaria control, necessitating urgent enhanced surveillance and alternative treatment strategies. Keywords Antimalarial resistance, Uganda, Pfk13, Pfdhfr, Pfdhps Pfmdr1, Pfcrt