Renal function outcomes in patients receiving TDF-containing antiretroviral therapy:

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dc.contributor.authorKalemeera, Francis
dc.contributor.authorOberholster, Carla
dc.contributor.authorSegamwenge, Innocent
dc.contributor.authorKibuule, Dan
dc.contributor.authorNaikaku, Ester
dc.contributor.authorMwangana, M.
dc.contributor.authorGodman, Brian
dc.date.accessioned2023-08-25T09:37:29Z
dc.date.available2023-08-25T09:37:29Z
dc.date.issued2018
dc.descriptionResearch article
dc.description.abstractIntroduction and Aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implications. Consequently, the aim of this paper is to correct this. Methods: Longitudinal retrospective study, with renal function assessed pre-cART and at various time points on cART using the Cockcroft-Gault method. The data source was the patients’ care booklets. Results: 71 patients were included. The majority were adults and female. Before cART initiation, 70.4% and 29.6% had abnormal and normal CrCl, respectively. CrCl was normalised in 24% of patients, while abnormal in the remainder. The mean (median) time to normalisation was 47.4 (33.7) months, observed more in paediatric than adult patients (p = 0.014). However, in paediatric patients, normalisation took longer than in adult patients. The reduction in CrCl, was observed at variable time points. 9/16 patients experienced a decline during first-line cART and 7 of these were receiving TDF. 7/16 experienced this during second-line cART and 6 were receiving TDF. Conclusion: HIV is typically the cause of renal impairment prior to cART, with TDF likely to be the cause of renal impairment during cART. Consequently, co-administration of TDF with other nephrotoxic drugs should be undertaken with caution if unavoidable. Overall, improvement in renal impairment was faster in adults.
dc.description.sponsorshipUniversity of Namibia, Oshakati Intermediate Hospital, Busitema University
dc.identifier.citationKalemeera, F., Oberholster, C., Segamwenge, I., Kibuule, D., Naikaku, E., Mwangana, M., & Godman, B. (2018). Renal function outcomes in patients receiving TDF-containing antiretroviral therapy: A retrospective pilot study in Namibia. International Journal of Pharmaceutical Sciences and Research, 9(10), 4273-4279.
dc.identifier.issn0975-8232
dc.identifier.issn2320-5148
dc.identifier.urihttps://doi.org/10.60682/zqk5-9t17
dc.language.isoen
dc.publisherInternational Journal of Pharmaceutical Sciences and Research
dc.relation.ispartofseriesInternational Journal of Pharmaceutical Sciences and Research; Volume 9, Issue 10
dc.subjectResearch Subject Categories::MEDICINE::Physiology and pharmacology::Pharmacological research::Pharmacology
dc.titleRenal function outcomes in patients receiving TDF-containing antiretroviral therapy:
dc.title.alternativea retrospective pilot study in Namibia
dc.typeArticle
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